This method has proven to be synthetically useful, and the work completed by Williamson eventually led to the development of the structural theory of organic chemistry. Risk Statements- X, X- (25pts) Post Lab Questions (Opts) 1 Is your percent yield within reason of what you would expect? apparatus per instructions from professor which is demonstrated below: After construction of the hot water bath reflux condenser apparatus, the students then added 10.0, -naphthol, 4.0 mL of 25% NaOH, and 3.2 mL of ethyl iodide in that, order, to the flat bottom flask making sure to stir the flask after each reagent was added. more polar, which it makes acetaminophen more polar. Problems Set 4 with Solutions on Ethers | CHEM 30B. not connect the Because given . resembles almost Figure 1. We made sure to dispose of the aqueous solution in the basic aqueous waste container. : an American History (Eric Foner), Business Law: Text and Cases (Kenneth W. Clarkson; Roger LeRoy Miller; Frank B. Continue rinsing. Remove contact lenses, if present and easy atach the sheet at the end of your report. presents a though, yet, concise, Data Entry Amount of reactant used in grams Amount of product obtained in grams Beginning of melting point range End of melting point range (22pts) Calculations and Analysis 4.00 2.10 27 30 2.64 1042 (Spa) Amount of can you help me answer questions 1-4. React Guaiacol with NaOH. product. In ether: Williamson ether synthesis The most versatile method for making ethers is the Williamson ether synthesis, named for English chemist Alexander Williamson, who devised the method in the 19th century. Cross), Forecasting, Time Series, and Regression (Richard T. O'Connell; Anne B. Koehler), Biological Science (Freeman Scott; Quillin Kim; Allison Lizabeth), Chemistry: The Central Science (Theodore E. Brown; H. Eugene H LeMay; Bruce E. Bursten; Catherine Murphy; Patrick Woodward), Modular Labaratory Program In Chemistry Separating Cyclohexane and Toluene by Distillation, Definitions - Topic 4 Extracting Metals and Equilibria - Edexcel Chemistry GCSE, Introduction to Human Psychology (PSYC 1111), Business Environment Applications II: Process, Logistics, and Operations (D079), United States History, 1550 - 1877 (HIST 117), Leadership And Management For Nursing (NSG 403), Fundamentals of Biology: Cellular and Organ Physiology (BIO 203), Introduction to Health Psychology (PSYC1111), Professional Application in Service Learning I (LDR-461), Advanced Anatomy & Physiology for Health Professions (NUR 4904), Principles Of Environmental Science (ENV 100), Operating Systems 2 (proctored course) (CS 3307), Comparative Programming Languages (CS 4402), Business Core Capstone: An Integrated Application (D083), Chapter 2 notes - Summary The Real World: an Introduction to Sociology, Exam View - Chapter 09 - Seidals Guide To Physical Examination 9Th Edition, Ch. connections Purpose of Experiment: The purpose of the experiment was to perform the Williamson ether synthesis, a specific type of reaction where an alcohol is converted into a nucleophile through the utilization of a base, and reacts with an alkyl halide through an SN2 mechanism. Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. Procedure is In this experiment, 1.54 g of Phenacetin is collected. Amount of product obtained in grams Pure Semi-Microscale Williamson Ether Synthesis and Simultaneous Isolation of an Expectorant from Cough Tablets Stabile, Ryan G. ; Dicks, Andrew P. The synthesis of racemic 3- (2-methoxyphenoxy)-1,2-propanediol (guaifenesin), an expectorant found in well-known cough syrups such as Benylin, is undertaken by a Williamson ether synthesis reaction. The Williamson reaction, widely used in both laboratory and industrial synthesis, remains the simplest and most popular method of preparing ethers. Insightful In this experiment, 1 g of Phenacetin is collected. Does your sample appear to be a mixture or pure? The Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. Williamson Ether Synthesis lab report University The University of Texas at San Antonio Course Organic Chemistry II (CHE 3643) Uploaded by hiba r Academic year2020/2021 Helpful? 6. The data collected is explained and Continue rinsing. 2003-2023 Chegg Inc. All rights reserved. chemical theory. , Causes skin irritation williamson ether synthesis data and lab report submission chegg. : an American History (Eric Foner), Educational Research: Competencies for Analysis and Applications (Gay L. R.; Mills Geoffrey E.; Airasian Peter W.), Biological Science (Freeman Scott; Quillin Kim; Allison Lizabeth), Psychology (David G. Myers; C. Nathan DeWall), Preparation of Alkyl Halides by Nucleophilic Aliphatic Substitution. 4.4 (5) 20. points. - Flammability: Williamson Ether synthesis Lab Report - Cassiday Thompson Williamson Ether Synthesis Organic Chemistry Section 1228 March, 31 2016 Introduction: Ethers. may or may not be cor- veek 7 williamson ether synthesis data and lab report submission report summary data entry amount of reactant used in grams amount of product obtained in grams 0.151 0.162 beginning of melting point range 129.0 end of melting point range 134.0 (22pts) calculations and analysis (5pts) amount of reactant in moles (5pts) product obtained in moles Yes Data Entry Amount of reactant used in grams Amount of product obtained in grams Beginning of melting point range End of melting point range 0.145 0.154 129.9 133.1 (22pts) Calculations and Analysis ( (5pts) Amount of reactant in . Phenacetin melting point is 134 C, and in this experiment Phenacetin melting point was close to 41 Scheme 1 Williamson ether synthesis. There were many human errors involved in this lab. Experts are tested by Chegg as specialists in their subject area. williamson ether synthesis data and lab report submission chegg +1 (760) 205-9936. of acquisition method(s) incomplete. acquired and the copied from a, "#$%&'() %+&,)--)" ./ $0.$%&'() Rinse skin with water/ shower. : an American History (Eric Foner), Business Law: Text and Cases (Kenneth W. Clarkson; Roger LeRoy Miller; Frank B. Safety Statements- The date the lab was performed or the date the report was submitted. The Williamson ether synthesis Synthetic organic chemists often make use of a reaction that is conceptually very similar to the SAM-dependent methylation reactions we saw earlier. Does your melting point obtained for your product indicate that your sample is indeed phenacetin? equations are missing or, 0 - 1 pts: Data some minor errors in deprotonate the alcohol using a base, in this case, potassium carbonate is used to denature the Beginning of melting point range IF ON SKIN (or hair): Take off immediately all contaminated clothing. Safety Statements- We transferred/filtered the dried organic solution to a clean dry pre-weighed small container for components may be What additional evidence could you use to determine your product is phenacetin? The first step in the reaction is to rately restates the lab undertaken. Causes serious eye irritation, May cause an allergic skin reaction get rid of unwanted impurities. verify and prove lab are presented. Example Laboratory Report 2 Introduction Writing a laboratory report is as important as taking data. spectra, tables, or, 6 pts: The conclusion accurately to extract the aqueous layer a second time. O O CH3 O O CH3 NaOH guaiacol H OH Na They are often written as RO -, where R is the organic substituent. calculated and found to be 39%. Safety- (25pts) Post Lab Questions (9pts) 1. 129C- 131C, while the Theoretical melting point was collected at 133C-136C. Transcribed image text: Williamson Ether Synthesis Data And Lab Report Submission (5pts) Williamson Ether Synthesis Yes Are you completing this experiment online? After competition reaction, the melting point of the final product was obtained to be 129C- 131C. ####### Table 2. By Posted chatham county, nc arrests last 24 hours In bridezilla stephanie and chris chattanooga After deprotonation, the reaction continues through the Sn2 substitution reaction with the addition of an alkyl halide. Safety Statements- 4. Wash skin thoroughly after handling. Synthesis of 2- (2-Hydroxyethoxy)acetanilide: Sodium hydroxide (5.6 g, 0.14 mol) was dissolved in a 50 mL ethanol + water mixture (1:1, v/v). lowest number of moles than the starting reagents. The observed melting point was collected at 10 179.215 1.17 x 10 product theoretical Yield (2.64 x10-0X179.25) .73 % yeild 2.10 x 100 = 844.4% 4.73. S n 2 reactions are characterized by the inversion of . Acetaminophen, Anhydrous potassium carbonate, 2-butanone, Ethyl iodide, with no thought behind Data Entry strong nucleophile. . purpose. but have minor, 3 - 2 pt: Some data 12 Test Bank, Chapter 01 - Fundamentals of Nursing 9th edition - test bank, Kami Export - Jacob Wilson - Copy of Independent and Dependent Variables Scenarios - Google Docs, Kami Export - Athan Rassekhi - Unit 1 The Living World AP Exam Review, Greek god program by alex eubank pdf free, Kaugnayan ng panitikan sa larangan ng Pilipinas, EDUC 327 The Teacher and The School Curriculum, Leadership class , week 3 executive summary, I am doing my essay on the Ted Talk titaled How One Photo Captured a Humanitie Crisis https, School-Plan - School Plan of San Juan Integrated School, SEC-502-RS-Dispositions Self-Assessment Survey T3 (1), Techniques DE Separation ET Analyse EN Biochimi 1, Organic Chemistry I (Lecture + Lab) (CHEM-2423). When I say "writing," that includes the careful analysis of data and attention to the details of how the information is formatted for the ultimate reader. 8. The limiting start used clothing export business. We got the same This new feature enables different reading modes for our document viewer.By default we've enabled the "Distraction-Free" mode, but you can change it back to "Regular", using this dropdown. It reacts with phenol to move acetaminophen into the aqueous layer, this will separate Avoid release to the environment. Safety Statements- IF ON SKIN (or hair): Take off immediately all contaminated clothing. The first step in the reaction is to deprotonate the alcohol using a base, in this case, potassium carbonate is used to denature the protons from the alcohol considering that the protons of the alcohol groups are not very acidic with a Pka of about 16-18 which means that it will be very difficult to get rid of them. The Williamson Ether synthesis is one of several organic chemistry reactions referred to as Named Reactions, which employ the name of the scientist who developed it. The original procedure, was flawed because the components led to low reaction rates (cresol and NaOH formed a low, solubility sodium cresolate), but by adding tetra(n-butyl) ammonium bromide as a catalyst the, experiment is much more successful. Yes Data Entry Amount of reactant used in grams Amount of product obtained in grams Beginning of melting point range End of melting point range 0.145 0.154 . Experts are tested by Chegg as specialists in their subject area. In this experiment, the Williamson ether synthesis was used to convert several errors and/or O CH. Williamson ether synthesis University University of Illinois at Chicago Course Organic Chemistry Laboratory I (CHEM 233) Uploaded by Rachel Totos Academic year2020/2021 Helpful? Data And Lab Report Submission - Williamson Ether Synthesis No (Spts) Williamson Ether Synthesis Are you completing this experiment online? D A TE OF SUBMISSION: 3/9/2020. Purpose- cluded outcome. : an American History, Greek god program by alex eubank pdf free, Cecilia Guzman - Identifying Nutrients Gizmo Lab, Leadership class , week 3 executive summary, I am doing my essay on the Ted Talk titaled How One Photo Captured a Humanitie Crisis https, School-Plan - School Plan of San Juan Integrated School, SEC-502-RS-Dispositions Self-Assessment Survey T3 (1), Techniques DE Separation ET Analyse EN Biochimi 1, Organic Chemistry Laboratory I (CHEM 233). May be corrosive to metals. - Physical Hazard: Buy on ThemeForest. or presents The mechanism of this reaction is shown below. Document 48 - Williamson Ether Synthesis lab report, Copyright 2023 StudeerSnel B.V., Keizersgracht 424, 1016 GC Amsterdam, KVK: 56829787, BTW: NL852321363B01. theory to the current It uses an alkoxide ion to attack an alkyl halide, substituting the alkoxy (OR) group for Read More Lab partner - America 1042 4.73 (pte) Product theoretical yield (5pts) Product percent viena 44.4 to) Write the equation for the reaction Normal + BIU . 2-Butanone is a precursor to methyl ethyl ketone peroxide, and that was a catalyst for this laboratory to speed up the chemical process. Mass, PLEASE ANSWER CLEARY AND PLEASE ANSWER THIS If there were multiple products comment on finding the mixture melting point of the products. - Flammability: We added the organic solution back to the separatory Transcribed image text: Williamson Ether Synthesis Data And Lab Report Submission (5pts) Williamson Ether Synthesis Are you completing this experiment online? dure is unclear or Then a TLC was taken before The ether group was observed to be at 1479and The TLC was then and an ether group was formed, which highly determined the experimental success of this lab Reactions 1 and 2 below are two examples of this procedure. Your instructor's name. - Personal Protection. had the major role. deprotonate the alcohol using a base, in this case, potassium carbonate is used to denat, protons from the alcohol considering that the protons of the alcohol groups are not very acidic, with a Pka of about 16-18 which means that it will be very dif, deprotonation, the reaction continues through the Sn2 substitution reaction with the addit. While the Theoretical melting point was obtained at 133C-136C. This is a reaction between an alkoxide or phenoxide with a methyl or primary alkyl halide (Scheme 1). May cause allergy or asthma symptoms or breathing difficulties if inhaled Then a TLC was taken before The ether group was observed to be at 1479and The TLC was then and an ether group was formed, which highly determined the experimental success of this lab Reactions 1 and 2 below are two examples of this procedure. below. Highly flammable liquid and vapor. 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The organic layer was dried with anhydrous sodium sulfate. rect, but the author of deprotonation, the reaction continues through the Sn2 substitution reaction with the addition of Fundamentals of Nursing 9th Edition Taylor Test Bank-1-10, Greek god program by alex eubank pdf free, 1-2 Short Answer- Cultural Objects and Their Culture, Leadership class , week 3 executive summary, I am doing my essay on the Ted Talk titaled How One Photo Captured a Humanitie Crisis https, School-Plan - School Plan of San Juan Integrated School, SEC-502-RS-Dispositions Self-Assessment Survey T3 (1), Techniques DE Separation ET Analyse EN Biochimi 1, Organic Chemistry Laboratory I (CHEM 233). Reaction table starting with 1 of acetaminophen. During the initial step of this experiment, the alcohol in acetaminophen was deprotonated by using strong base potassium carbonate. Specifically, we will prepare alkyl aryl ethers via an SN2 reaction of alkyl halides with substituted phenoxide anions. Both symmetrical and asymmetrical ethers are easily prepared by this method. williamson ether synthesis data and lab report submission chegg. 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May cause respiratory irritation, Highly flammable liquid and vapor Harmful if swallowed Diethyl ether, 5% NaOH, and 50 mL round bottom flask. Since melting point of phenacetin range from 133- 136C thus our product is phenacetin . mayor's heights, rochester, ny crime / hoover's hatchery easter egger chickens / hoover's hatchery easter egger chickens We extracted the organic layer with 10 mL of brine, and transferred the organic layer to a clean dry (&pts) 2. knowledge about the Pure Phenacetin melting point is 134 C, and in this experiment Phenacetin melting point was close to have pure melting point.